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DPV RulesAll rules are available to any client free of charge and new rules created by a client become part of the rule library open to all. The VigiLanz Rule Builder allows the user with authorized privileges to build rules easily and quickly using drop down menus that show all the formulary drugs and all the Hospital's labs. The user makes drug and lab selections and fills in other required fields such as whether the lab is a high or low lab and the lab values they desire for the rule to fire. An optional value that can be specified is a Good Medical Practice Interval (GMP). This is a time period either fixed or variable that the VigiLanz system uses to reduce the number of alerts. If a rule is satisfied by a correct drug action within this period that activation of that rule will not become an alert. Thus if a physician in the normal course of rounds makes a change in the drug regime within the time period the pharmacist will not have to intervene. The use of a specified GMP interval allows time for a clinician to make the appropriate change in a non-critical situation which turns off a rule activation with this new drug order meeting the specified criteria and is key to reducing pharmacists' workload due to over alerting.. Past lab values can be made part of the rule so that not only does the current lab have to be greater or less than the cutoff value but also the previous lab values have to bare a user chosen relation to the current lab. This allows comparison to baseline values e.g. the Maximum or Minimum or Average or Median or the immediately previous lab of all the patient's previous labs has to be less/more than X% (or some distinct value you choose) of the current lab for the rule to fire.) Filters can be chosen that restrict the scope of the rule for age, gender, weight, Unit of the Hospital or prescribing Physician. Associated drugs and/or labs can also be chosen that qualify the rule even further so that the rule will only activate if that set of additional drugs/labs are present as well as all the other parameters that are set in the rule. Each rule directs a correct drug action chosen by the user that will satisfy the rule. This can be raise or lower the dose, discontinue the drug, change the dosing schedule etc. all through choices available through drop down menus that display the available options. If a rule is satisfied within the Good Medical Practice Interval it will not become an alert and will disappear in the warning phase from the action screens. If not satisfied in time or the drug action is incorrect it will become an alert. The rule can be given accelerators such that very abnormal or trending labs call for faster or slower action. Rules can be created, edited, put into production, taken out
of production and assigned to clinical rule groups as the user wishes.
Rules can also be cloned so that a rule for one drug/lab/weight range/age etc.
can easily be made for a another in an instant. DPV Rule ExamplesDrug induced hyperkalemia ACEI, ARB and K >5 Critical drug levels (low and high) Carbamazepine, lithium, digoxin, phenobarbital,Theophylline Drug induced hypoglycemia Insulin and glucose <40, 70Oral hypoglycemic drugs and glucose <40, 70
Anticoagulation monitoring Alerts to sub therapeutic PTT while on heparin.INR >3. Thrombocytopenia in patients receiving enoxaparin whose platelets have dropped at least 30% AND are <200. Heparin induced thrombocytopenia identification. Alerts to the need to increase prophylaxis dose of enoxaparin for CrCl>30 ml/min and wt>50kg to 40 mg q24h. Heparin induced thrombocytopenia identification Alerts to the possibility of HIT with a positive heparin associated platelet antibody result. Check for heparin/enoxaparin use and need for DTI. Alerts to the possible need to discontinue enoxaparin in a patient with INR >2.
Drug induced thrombocytopenia Ranitidine and platelets have FALLEN 50 percent of previous value andany of last platelet (PLT) results within last 3 days are < 100. Thrombocytopenia in patients on methotrexate and probenecid.
Reversal agent use i.e. ADR tracer drug alert Patients who are receiving protamine as antidote for anticoagulation.Patients receiving phytonadione while receiving warfarin. Patient receiving Flumazenil as antidote to benzodiazepine toxicity. Flumazenil taken from Pyxis. Evaluate for possible ADR. Glucagon taken from Pyxis.Evaluate for possible ADR- hyhypoglycemia or beta blocker toxicity.
Drug induced hepatotoxicity Rule designed to monitor elevations in liver function tests with fluvastatin.ALT (SGPT) or AST (SGOT) > 450 and check any of the last ALT/AST results during the last 7 days is <450 has risen 20% of the previous value. Rule designed to monitor elevations in liver function tests with lovastatin. ALT (SGPT) or AST (SGOT) > 450 and check any of the last ALT/AST results during the last 7 days is <450 has risen 20% of the previous value.
Renal Dose rules Alerts to the need to increase levofloxacin dose with CrCl >50 ml/min to 500-750 mg/day.Alerts to the need to increase levofloxacin dose with CrCl >50 ml/min to 500-750 mg/day. Alert to the need to use metformin with caution for CrCl=30-60, and DC if CrCl<30. Alerts to a possible dose adjustment for amikacin to 7.5 mg/kg/day for a CrCl = 40-60 ml/min using Adjusted Body Weight (ABW).
Anticonvulsant therapy Alerts to toxic levels of total phenytoin in patients receiving amiodarone, allopurinol, or warfarin.Alerts to toxic levels of valproic acid. Phenytoin level greater than 18 and Albumin less than 3.3. << Back to DPV |
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