VigiLanz patient monitoring software helps physicians and pharmacists identify and prevent adverse drug events

DPV Rules

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All rules are available to any client free of charge and new rules created by a client become part of the rule library open to all. The VigiLanz Rule Builder allows the user with authorized privileges to build rules easily and quickly using drop down menus that show all the formulary drugs and all the Hospital's labs. The user makes drug and lab selections and fills in other required fields such as whether the lab is a high or low lab and the lab values they desire for the rule to fire. An optional value that can be specified is a Good Medical Practice Interval (GMP). This is a time period either fixed or variable that the VigiLanz system uses to reduce the number of alerts. If a rule is satisfied by a correct drug action within this period that activation of that rule will not become an alert. Thus if a physician in the normal course of rounds makes a change in the drug regime within the time period the pharmacist will not have to intervene. The use of a specified GMP interval allows time for a clinician to make the appropriate change in a non-critical situation which turns off a rule activation with this new drug order meeting the specified criteria and is key to reducing pharmacists' workload due to over alerting..

Past lab values can be made part of the rule so that not only does the current lab have to be greater or less than the cutoff value but also the previous lab values have to bare a user chosen relation to the current lab. This allows comparison to baseline values e.g. the Maximum or Minimum or Average or Median or the immediately previous lab of all the patient's previous labs has to be less/more than X% (or some distinct value you choose) of the current lab for the rule to fire.)

Filters can be chosen that restrict the scope of the rule for age, gender, weight, Unit of the Hospital or prescribing Physician. Associated drugs and/or labs can also be chosen that qualify the rule even further so that the rule will only activate if that set of additional drugs/labs are present as well as all the other parameters that are set in the rule.

Each rule directs a correct drug action chosen by the user that will satisfy the rule. This can be raise or lower the dose, discontinue the drug, change the dosing schedule etc. all through choices available through drop down menus that display the available options. If a rule is satisfied within the Good Medical Practice Interval it will not become an alert and will disappear in the warning phase from the action screens. If not satisfied in time or the drug action is incorrect it will become an alert.

The rule can be given accelerators such that very abnormal or trending labs call for faster  or slower action. 

Rules can be created, edited, put into production, taken out of production and assigned to clinical rule groups as the user wishes. Rules can also be cloned so that a rule for one drug/lab/weight range/age etc. can easily be made for a another in an instant.
  
The following are Rule Descriptions only.  All the details that make up each rule are easily seen in the Rule Builder and can be viewed as a group within the Vigilanz Report System. Here we show only the rule description that the user created.  It should give a general sense of why the rule was created. For a closer look at our rules think of calling or writing for an online demo.

DPV Rule Examples

Drug induced hyperkalemia

ACEI, ARB and K >5
Potassium supplements and K>5

Critical drug levels (low and high)

Carbamazepine, lithium, digoxin, phenobarbital,Theophylline
Digoxin level >2.0, evaluate for possible ADR or dose adjustment
Elevated theophylline >20, evaluate for possible ADR or dose adjustment
Elevated carbamazepine level >12, evaluate for possible ADR, or dose adjustment

Drug induced hypoglycemia

Insulin and glucose <40, 70
Oral hypoglycemic drugs and glucose <40, 70

Anticoagulation monitoring

Alerts to sub therapeutic PTT while on heparin.
INR >3.
Thrombocytopenia in patients receiving enoxaparin
whose platelets have dropped at least 30% AND are <200.
Heparin induced thrombocytopenia identification.
Alerts to the need to increase prophylaxis dose of enoxaparin
for CrCl>30 ml/min and wt>50kg to 40 mg q24h.
Heparin induced thrombocytopenia identification
Alerts to the possibility of HIT with a positive heparin associated platelet antibody result.
Check for heparin/enoxaparin use and need for DTI.
Alerts to the possible need to discontinue enoxaparin in a patient with INR >2.

Drug induced thrombocytopenia

Ranitidine and platelets have FALLEN 50 percent of previous value and
any of last platelet (PLT) results within last 3 days are < 100.
Thrombocytopenia in patients on methotrexate and probenecid.

Reversal agent use i.e. ADR tracer drug alert

Patients who are receiving protamine as antidote for anticoagulation.
Patients receiving phytonadione while receiving warfarin.
Patient receiving Flumazenil as antidote to benzodiazepine toxicity.
Flumazenil taken from Pyxis. Evaluate for possible ADR.
Glucagon taken from Pyxis.Evaluate for possible ADR- hyhypoglycemia or beta blocker toxicity.

Drug induced hepatotoxicity

Rule designed to monitor elevations in liver function tests with fluvastatin.
ALT (SGPT) or AST (SGOT) > 450 and check any of the last ALT/AST results
during the last 7 days is <450 has risen 20% of the previous value. Rule designed to monitor elevations in liver function tests with lovastatin.
ALT (SGPT) or AST (SGOT) > 450 and check any of the last ALT/AST results
during the last 7 days is <450 has risen 20% of the previous value.

Renal Dose rules

Alerts to the need to increase levofloxacin dose with CrCl >50 ml/min to 500-750 mg/day.
Alerts to the need to increase levofloxacin dose with CrCl >50 ml/min to 500-750 mg/day.
Alert to the need to use metformin with caution for CrCl=30-60, and DC if CrCl<30.
Alerts to a possible dose adjustment for amikacin to 7.5 mg/kg/day
for a CrCl = 40-60 ml/min using Adjusted Body Weight (ABW).

Anticonvulsant therapy

Alerts to toxic levels of total phenytoin in patients receiving amiodarone, allopurinol, or warfarin.
Alerts to toxic levels of valproic acid.
Phenytoin level greater than 18 and Albumin less than 3.3.



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